ERIC Number: EJ785564
Record Type: Journal
Publication Date: 2008-Feb
Reference Count: 0
Reconsolidation of Appetitive Memories for Both Natural and Drug Reinforcement Is Dependent on [beta]-Adrenergic Receptors
Milton, Amy L.; Lee, Jonathan L. C.; Everitt, Barry J.
Learning & Memory, v15 n2 p88-92 Feb 2008
We have investigated the neurochemical mechanisms of memory reconsolidation and, in particular, the functional requirement for intracellular mechanisms initiated by [beta]-adrenergic signaling. We show that propranolol, given in conjunction with a memory reactivation session, can specifically disrupt the conditioned reinforcing properties of a previously appetitively reinforced conditioned stimulus (CS), whether the stimulus had been associated with self-administered cocaine or with sucrose. These data show that memories for both drug and nondrug CS-US associations are dependent on [beta]-adrenergic receptor-mediated signaling for their reconsolidation, with implications for the potential development of a novel treatment for drug addiction and some forms of obesity.
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Authoring Institution: N/A