ERIC Number: EJ785561
Record Type: Journal
Publication Date: 2008-Feb
Reference Count: 0
Distinct Single but Not Necessarily Repeated Tetanization Is Required to Induce Hippocampal Late-LTP in the Rat CA1
Sajikumar, Sreedharan; Navakkode, Sheeja; Frey, Julietta U.
Learning & Memory, v15 n2 p46-49 Feb 2008
The protein synthesis-dependent form of hippocampal long-term potentiation (late-LTP) is thought to underlie memory. Its induction requires a distinct stimulation strength, and the common opinion is that only repeated tetani result in late-LTP whereas as single tetanus only reveals a transient early-LTP. Properties of LTP induction were compared to learning processes where repetition is often the prerequisite for a long-lasting memory. However, also single events can lead to manifested memory. If LTP subserves processes of learning, similar results should be detectable for LTP. Here we show that a single tetanus is sufficient to induce late-LTP requiring dopaminergic co-transmission during induction.
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
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