ERIC Number: EJ784705
Record Type: Journal
Publication Date: 2008
Reference Count: 101
Sensory Processing Disorder in a Primate Model: Evidence from a Longitudinal Study of Prenatal Alcohol and Prenatal Stress Effects
Schneider, Mary L.; Moore, Colleen F.; Gajewski, Lisa L.; Larson, Julie A.; Roberts, Andrew D.; Converse, Alexander K.; DeJesus, Onofre T.
Child Development, v79 n1 p100-113 Jan-Feb 2008
Disrupted sensory processing, characterized by over- or underresponsiveness to environmental stimuli, has been reported in children with a variety of developmental disabilities. This study examined the effects of prenatal stress and moderate-level prenatal alcohol exposure on tactile sensitivity and its relationship to striatal dopamine system function in thirty-eight 5- to 7-year-old rhesus monkeys. The monkeys were from four experimental conditions: (a) prenatal alcohol exposed, (b) prenatal stress, (c) prenatal alcohol exposed + prenatal stress, and (d) sucrose controls. Increased D2 receptor binding in the striatum, evaluated using positron emission tomography neuroimaging, was related to increased withdrawal (aversion) responses to repetitive tactile stimuli and reduced habituation across trials. Moreover, prenatal stress significantly increased overall withdrawal responses to repetitive tactile stimulation compared to no prenatal stress.
Descriptors: Stimuli, Stimulation, Developmental Disabilities, Fetal Alcohol Syndrome, Sensory Integration, Animals, Prenatal Influences, Control Groups, Biochemistry, Diagnostic Tests, Tactual Perception, Withdrawal (Psychology)
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
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