ERIC Number: EJ783914
Record Type: Journal
Publication Date: 2008-Feb
Reference Count: 0
Are There Enhanced MBP Autoantibodies in Autism?
Libbey, Jane E.; Coon, Hilary H.; Kirkman, Nikki J.; Sweeten, Thayne L.; Miller, Judith N.; Stevenson, Edward K.; Lainhart, Janet E.; McMahon, William M.; Fujinami, Robert S.
Journal of Autism and Developmental Disorders, v38 n2 p324-332 Feb 2008
Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism.
Descriptors: Play, Autism, Anatomy, Pervasive Developmental Disorders, Biochemistry, Neuropsychology, Control Groups, Individual Differences, Brain
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A