ERIC Number: EJ783908
Record Type: Journal
Publication Date: 2008-Feb
Reference Count: 0
How Relevant Are GFAP Autoantibodies in Autism and Tourette Syndrome?
Kirkman, Nikki J.; Libbey, Jane E.; Sweeten, Thayne L.; Coon, Hilary H.; Miller, Judith N.; Stevenson, Edward K.; Lainhart, Janet E.; McMahon, William M.; Fujinami, Robert S.
Journal of Autism and Developmental Disorders, v38 n2 p333-341 Feb 2008
Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with Tourette Syndrome (24) by enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to GFAP, not accounted for by age, between the Tourette (significantly lower) and regressive autism groups. However, no differences were found between: classic/regressive; classic/controls; classic/Tourette; regressive/controls; or controls/Tourette. Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome.
Descriptors: Neurological Impairments, Autism, Anatomy, Biochemistry, Role, Children, Control Groups
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Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A