ERIC Number: EJ782401
Record Type: Journal
Publication Date: 2008-Jan
Reference Count: 0
Brief Report: Plasma Leptin Levels Are Elevated in Autism: Association with Early Onset Phenotype?
Ashwood, Paul; Kwong, Christina; Hansen, Robin; Hertz-Picciotto, Irva; Croen, Lisa; Krakowiak, Paula; Walker, Wynn; Pessah, Isaac N.; Van de Water, Judy
Journal of Autism and Developmental Disorders, v38 n1 p169-175 Jan 2008
There is evidence of both immune dysregulation and autoimmune phenomena in children with autism spectrum disorders (ASD). We examined the hormone/cytokine leptin in 70 children diagnosed with autism (including 37 with regression) compared with 99 age-matched controls including 50 typically developing (TD) controls, 26 siblings without autism, and 23 children with developmental disabilities (DD). Children with autism had significantly higher plasma leptin levels compared with TD controls (p less than 0.006). When further sub-classified into regression or early onset autism, children with early onset autism had significantly higher plasma leptin levels compared with children with regressive autism (p less than 0.042), TD controls (p less than 0.0015), and DD controls (p less than 0.004). We demonstrated an increase in leptin levels in autism, a finding driven by the early onset group.
Descriptors: Siblings, Autism, Developmental Disabilities, Correlation, Children, Metabolism, Comparative Analysis, Symptoms (Individual Disorders)
Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: email@example.com; Web site: http://www.springerlink.com
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Authoring Institution: N/A