The article reports that a wayward research project shattered the trust last year between Arizona State University and a small American Indian tribe in the bottom of the Grand Canyon. This scandal exposed once again the need for tribal governments and Native American communities to get involved in regulating research on human subjects. In response to this need, tribal colleges and universities are slowly but increasingly adopting procedures to make themselves gatekeepers for research conducted at their schools and among their affiliated American Indian communities. They want to prevent exploitation of Indian people, train their own students in research and encourage the medical research field to meet the health needs of the Indian community.