ERIC Number: EJ747839
Record Type: Journal
Publication Date: 2006-Apr
Reference Count: N/A
A Crossover Study of Risperidone in Children, Adolescents and Adults with Mental Retardation
Hellings, Jessica A.; Zarcone, Jennifer R.; Reese, R. Matthew; Valdovinos, Maria G.; Marquis, Janet G.; Fleming, Kandace K.; Schroeder, Stephen R.
Journal of Autism and Developmental Disorders, v36 n3 p401-411 Apr 2006
Risperidone has shown safety and efficacy for aggressive and destructive behaviors in short-term studies. This longer-duration study includes a broad sample. Forty subjects, aged 8-56 years (mean=22), all with mental retardation and 36 with autism spectrum disorders participated in this 22-week crossover study, with 24 weeks of open maintenance thereafter. Of 40 subjects, 23 (57.5%) responded fully (50% decrease in Aberrant Behavior Checklist-Community Irritability subscale score), while 35 subjects (87.5%) showed a 25% decrease. Gender, mood disorder, and antiseizure medications did not alter response. Increased appetite and weight gain were common. Low dose risperidone was effective for aggressive behavior in persons with MR. More long-term studies are needed, incorporating weight control interventions.
Descriptors: Drug Therapy, Mental Retardation, Pervasive Developmental Disorders, Children, Adolescents, Adults, Pharmacology, Behavior Disorders, Body Weight, Measures (Individuals), Aggression
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Authoring Institution: N/A
Identifiers - Assessments and Surveys: Aberrant Behavior Checklist