Structural equation modeling (SEM) can be adapted in a relatively straightforward fashion to analyze data from interchangeable dyads (i.e., dyads in which the 2 members cannot be differentiated). The authors describe a general strategy for SEM model estimation, comparison, and fit assessment that can be used with either dyad-level or pairwise (double-entered) dyadic data. They present applications illustrating this approach with the actor-partner interdependence model, confirmatory factor analysis, and latent growth curve analysis.