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ERIC Number: EJ747744
Record Type: Journal
Publication Date: 2007
Pages: 13
Abstractor: Author
Reference Count: 17
ISSN: ISSN-1362-3613
A Placebo Double-Blind Pilot Study of Dextromethorphan for Problematic Behaviors in Children with Autism
Woodard, Cooper; Groden, June; Goodwin, Matthew; Bodfish, James
Autism: The International Journal of Research & Practice, v11 n1 p29-41 2007
We used a mixed group/single-case, double-blind, placebo-controlled, ABAB design to examine the safety and efficacy of the glutamate antagonist dextromethorphan for the treatment of problematic behaviors and core symptoms in eight children diagnosed with autism. All participants had increased levels of irritability at baseline as measured by the Aberrant Behavior Checklist, and demonstrated a wide variety of problematic behaviors. Group analyses revealed that dextromethorphan was equivalent to placebo in the treatment of problem behaviors and core symptoms. Analyses at the single-subject level demonstrated that three of the eight participants who had a behavioral profile consistent with attention-deficit hyperactivity disorder responded positively to dextromethorphan. Future research that employs a larger, more homogeneous sample is necessary to replicate the findings from this study. (Contains 3 tables and 2 figures.)
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Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Identifiers - Assessments and Surveys: Aberrant Behavior Checklist