The present case study examines how culture can influence behavior-based safety in different organizational settings and how behavior-based safety can impact different organizational cultures. Behavior-based safety processes implemented in two culturally diverse work settings are described. Specifically, despite identical implementation plans, similarities and differences in the actual implementation of the two behavior-based safety processes are presented with an emphasis on the effects of employee-driven decisions. Data on both implementations and outcome measures are provided. The results are discussed with respect to the potential impact of specific cultural variables.