This study examined the experiences of nine American Indian and Alaska Native (AI/AN) students in medical school with the purpose of gaining information about how to support students once they enrolled in medical school. In-depth interviews conducted while the participants were in medical school were used to generate data that were analyzed using grounded theory. How students reacted to professional socialization emerged as a key element in understanding their experiences. The study found that participants demonstrated resistance to the professional socialization process, which they resolved by accepting their roles as physician on their own terms.