The Darzens Condensation: Structure Determination through Spectral Analysis and Understanding Substrate Reactivity.

Crouch, R. David; Holden, Michael S.; Romany, Candice A.

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Peer reviewed

ERIC Number: EJ717051

Record Type: Journal

Publication Date: 2004-May-1

Pages: 2

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ISSN: ISSN-0021-9584

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The Darzens Condensation: Structure Determination through Spectral Analysis and Understanding Substrate Reactivity

Crouch, R. David; Holden, Michael S.; Romany, Candice A.

Journal of Chemical Education, v81 n5 p711-712 May 2004

The use of KOH and a phase transfer catalyst to achieve diastereoselective Darzens condensation is described and a modification of the method for use in organic chemistry is carried out. The experiment involves the condensation of t-butyl chloroacentate and p-tolualdehyde with KOH and benzyltriethylammonium chloride in THF.

Descriptors: Organic Chemistry, Science Experiments, Laboratory Experiments, Science Instruction, Chemistry, Teaching Methods, Spectroscopy

Journal of Chemical Education, Subscription Department, P.O. Box 1267, Bellmawr, NJ 08099-1267. Web site: http://jchemed.chem.wisc.edu/AboutJCE/contact.html.

Publication Type: Journal Articles; Reports - Descriptive

Education Level: N/A

Audience: N/A

Language: English

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