Single-case experimental designs are becoming more popular and acceptable ways to conduct classroom-based research. Single-case designs can also be beneficial when conducting literacy research. There are a variety of single-case research designs that can accommodate a range of instructional strategies and research questions. This paper provides examples and reasons for using the multiple baseline with literacy research. The effectiveness of multiple baseline designs are also examined in relation to the following experimental design issues: control, replication, causal relationships, internal and external validity and ethical concerns.