The authors examined psychological distress and relational patterns in college men and women. Peer, mentor, and community relationships; year in school; and family experiences were hypothesized to predict psychological distress, although predictive patterns were expected to differ in women and men. Overall, results supported the hypotheses. Findings are interpreted from the perspective of the relational-cultural model. Counseling implications focus on interventions congruent with the specific relational needs of women and men.