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ERIC Number: EJ697219
Record Type: Journal
Publication Date: 2005-Jul-1
Pages: 7
Abstractor: Author
Reference Count: 0
ISSN: ISSN-0890-8567
A Randomized, Double-Blind, Placebo-Controlled Trial of Metoclopramide for the Treatment of Tourette's Disorder.
Nicolson, Rob; Craven-Thuss, Beth; Smith, Judy; McKinlay, B. Duncan; Castellanos, F. Xavier
Journal of the American Academy of Child and Adolescent Psychiatry, v44 n7 p640 Jul 2005
Objective: The pattern of dopamine antagonism by metoclopramide suggests benefits in the treatment of tic disorders. The purpose of this study was to examine the efficacy and safety of metoclopramide in the treatment of children and adolescents with tic disorders. Method: Twenty-seven medication-free patients (age 11.9 [+ or -] 2.7 years) with Tourette's disorder or a chronic tic disorder participated in an 8-week double-blind, randomized, placebo-controlled trial of metoclopramide. Metoclopramide was started at 5 mg daily and titrated as needed to a maximum dose of 40 mg daily. Tics were rated every 2 weeks, and adverse effects, including weight, cardiac, and laboratory measures, were monitored. Results: After 8 weeks of treatment, subjects receiving metoclopramide showed a 39% reduction in their total tic score on the Yale Global Tic Severity Scale, while subjects receiving placebo showed only a 13% reduction in tic severity (p = .001). Metoclopramide was well tolerated with no significant laboratory or cardiac changes noted other than an increase in serum prolactin. Conclusions: The results of this small controlled study suggest that metoclopramide is an effective and well-tolerated treatment for children and adolescents with tic disorders. Further trials are needed to confirm its efficacy and safety in pediatric patients and adults. J. Am. Acad. Child Adolesc. Psychiatry, 2005;44(7):640-646. Key Words: Tourette's disorder, treatment, dopamine antagonist, metoclopramide.
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Publication Type: Journal Articles
Education Level: N/A
Audience: N/A
Language: N/A
Sponsor: N/A
Authoring Institution: N/A