ERIC Number: EJ696806
Record Type: Journal
Publication Date: 2005-Jan
Brain Activation Gradients in Ventrolateral Prefrontal Cortex Related to Persistence of ADHD in Adolescent Boys
Schulz, Kurt P.; Newcorn, Jeffrey H.; Fan, Jin; Tang, Cheuk Y.; Halperin, Jeffrey M.
Journal of the American Academy of Child and Adolescent Psychiatry, v44 n1 p47 Jan 2005
Objective: To explore the possible role that functional abnormalities of the prefrontal cortex and basal ganglia play in the persistence of attention-deficit/hyperactivity disorder (ADHD) in adolescents aged 15 to 19 years. Method: Ten male adolescents who were diagnosed with ADHD during childhood were grouped into those who continued to meet full diagnostic criteria for DSM-IV ADHD (persisters; n = 5) and those in whom symptoms had remitted sufficiently to warrant a diagnosis of ADHD in partial remission (remitters; n = 5). Persisters, remitters, and five carefully matched controls with no history of ADHD were scanned using functional magnetic resonance imaging while performing a go/no-go task. Results: Parallel linear trends were found in performance on the go/no-go task and activation of ventrolateral prefrontal cortex, such that persisters made the most commission errors (33%) and showed the greatest activation, remitters made fewer commission errors (24%) and had lower activity, and activation was lowest in controls who made the fewest errors (13%). Conclusions: These preliminary results suggest that developmental changes in ADHD symptomatology are associated with functional changes in ventrolateral prefrontal cortex activity.
Descriptors: Psychiatry, Persistence, Adolescents, Hyperactivity, Brain, Attention Deficit Disorders
Lippincott Williams & Wilkins, P.O. Box 1620, Hagerstown, MD 21741. Tel: 800-638-3030 (Toll Free); Fax: 301-223-2400.
Publication Type: Journal Articles; Reports - Evaluative
Education Level: N/A
Authoring Institution: N/A