The job of a researcher is to explain the phenomenon that he or she is seeking to understand. To do this requires the accumulation of facts. These facts are then interpreted to arrive at explanations. However, individual researchers often interpret facts in different ways and arrive at disparate explanations. In her book, Making Sense of Life, Evelyn Fox Keller (2002) outlines various approaches used by developmental biologists to understand the animate systems we call life. In this review, I note several parallels between biology and behavior analysis in how facts are discovered, what is an acceptable interpretation of data, and how explanations are arrived at.