This study investigates the effects of the Algodoo interactive learning program on fifth-grade students' achievement in science and motivation towards science. The research was carried out in the fall semester of the 2020-2021 academic year with the participation of 110 fifth grade students. In the study, a pre-test-post-test control group quasi-experimental design was used. Within the scope of the study, the "Force Measurement and Friction" unit was taught during three weeks through Algodoo in the experimental group and traditional teaching in the control group. In the study, data were collected through an achievement test including multiple-choice questions and Science Motivation Scale. Both instruments were applied to the groups twice as pre and post-test. Independent samples t-test was conducted separately for the quantitative data obtained from each instrument. Moreover, a paired-samples t-test was conducted to compare the pre-and post-test scores of each instrument. According to the findings, Algodoo applications had positive effects on science achievement and motivation towards science.