The current study aimed at using the Structural Equation Modeling (SEM) to detect the factors affecting the role of faculty members in university colleges for e-learning system (Moodle). The study has used the descriptive approach through the questionnaire tool which consisted in its final form of (33) items distributed on (10) factors. The study sample consisted of (487) faculty members in university colleges. The AMOS program was used to analyze the data using the Structural Equation Modeling (SEM) through the path analysis method and (goodness-of-fit) tests to test the validity of the proposed model. The results of the study identified (6) factors that affect the use of faculty members for the e-learning system (model) in the teaching process viz., the competence of faculty members, the efficiency of the e-learning system, training benefits, the influence of others, and facilities, in addition (3) factors were identified as outputs for the use of the faculty E-learning system namely quality of teaching, faculty satisfaction, and faculty confidence in the e-learning system. The study recommends educational policy makers in the Ministry of Higher Education, Scientific Research and University Administration to adopt these factors identified in this study and implement the effect of these factors on the use of faculty members for the e-learning system (Moodle) in order to achieve learning outcomes for academic programs.