The study aims at analyzing the effectiveness and practicality of BIL program to improve the generic skills in learning biology. This study was a pre-experimental study with one group pre-test and post-test design on 138 students divided into four groups at several universities in Mataram. The practicality of the program is measured using an observation sheet and effectiveness is measured by an essay test based on a generic skills rubric Data were analyzed using paired t-test, n-gain and ANOVA test. The results showed a significant increase in generic skills, p < 0.05, with an average n-gains of 0.09 to 0.53, and there were differences for the four groups. The practicality results show that the BIL program fulfills the practical requirements with observations of the implementation of learning by 97% in the good category. Thus, it can be concluded that the BIL program is effective and practical for improving generic skills.