This study aims to investigate students' attitudes towards e-book use, and its relationship to self-efficacy and academic motivation in Omani higher education institutions. The sample of the study, which was chosen based on the stratification random method, consisted of 200 students from both genders and different colleges and academic years. To achieve the aims of the study, a descriptive correlational approach was adopted using attitudes, academic motivation and self-efficacy scales developed by the researchers, and administered to the study sample after assessing their psychometric properties. Findings show generally a positive significant correlation between students' attitudes towards e-book use, self-efficacy, and academic motivation.