The study is aimed at solving a problem generated by the necessity to change the organizational forms of digital learning to prepare graduates who meet the requirements of today's labor market; who are equipped with teamwork skills and skills of project-management under uncertainty which are especially relevant nowadays. The purpose of the study is to provide a theoretical foundation for and experimentally verify the effectiveness of involving students in project teamwork on designing smart applications by means of modern digital technologies; project teamwork activities allow developing the skills and abilities characteristic of a strong research culture necessary for making future discoveries in science and technology. The research methods are the analysis and generalization of psychological and pedagogical literature, of development strategies and education theories; mathematical methods of statistics, psychodiagnostics and survey methods. The pedagogical experiment is illustrated by the example of assessing the development of teamwork skills, project management skills, and programming skills which form the basis for professional self-realization of graduates. The study results. The study specifies the concepts of the ability to work in a team and smart application in the context of training professionals for digital economy. The didactic potential of project team work in the sphere of self-realization of graduates is described. The authors reveal the characteristics, principles, and stages of team work on the project aimed at designing a smart application. They offer their recommendations regarding the process of planning and organizing team activities, specifying the skills and abilities necessary to help a person succeed in today's digital society and to get a profession which is in demand on the labor market. The authors draw a conclusion that project teamwork meets the requirements of digital education and contributes to successful professional self-realization of university graduates if it is well designed, accurately planned, and monitored by the educator to the extent necessary.