Although there has been growing interest in utilizing robots for intervention in autism spectrum disorder (ASD), there have been very few controlled trials to assess the actual impacts of such systems on social communication vulnerabilities. This study reports a randomized controlled trial to investigate a robot-mediated response to joint attention intervention in a small (23 recruited; 20 completed) group of young children (average age = 2.54 years) with ASD. Small and nonsignificant group differences were observed regarding improvements in response to joint attention skills within and beyond the intervention. The sample showed tremendous individual variability in response to the system. Results highlight the current challenges related to developing pragmatic, beneficial, and generalizable robotic intervention systems for the targeted population.