Infants and toddlers account for a disproportionate percentage of children diagnosed with cancer. These young children and their families benefit when infant and early childhood mental health is recognized as vital and integrated with medical treatment. Such interventions are beneficial for supporting families in coping when cancer is the only stressor, and they become even more essential when cancer is just one in a series of stressors impacting a family, as is often the case. The authors discuss three abridged stories of collaborative, interdisciplinary, family-centered services provided for young children with cancer and their families, elucidating the importance of supporting the whole family and the young child alike in the context of pediatric cancer treatment.