Liberal arts programs encompass a range of academic disciplines, and their effectiveness relies not only on what these disciplines are, but also on how they are integrated. The natural sciences are one important component of liberal arts programs that may be difficult to assimilate with the rest of the curriculum. In this paper, the topic of neglected tropical diseases is provided to illustrate an innovative approach to bridging transdisciplinary connections across and through disparate academic disciplines. This approach is supported by evidence from prior studies demonstrating the effectiveness of transdisciplinary teaching at promoting creativity, knowledge retention, and student motivation.