With an adult obesity rate of 35.6%, Alabama is the second most obese state in the United States. Alabama Extension and the Centers for Disease Control and Prevention (CDC) joined in the first collaboration between the CDC and land-grant institutions to prevent further incidence and reduce the prevalence of obesity. The objective of our study was to determine perceived barriers and assets related to nutrition education, food retail, and physical activity in 14 rural counties in Alabama where adult obesity rates are greater than 40%. Extension formed community coalitions in the counties to help identify community-specific needs and strategies related to obesity prevention and reduction.