In this thought leader commentary, we review the potential devastating effects of the COVID-19 pandemic on young people, including trauma, impacts on mental health, socioemotional distress, and changes in academic learning. Stating that 4-H is uniquely positioned to mitigate these effects through intentional positive youth development efforts, we present a call to action for 4-H educators and Extension administrators as we move from initial reaction to recovery and beyond. We recommend four research-based strategies to ensure that youths not only survive, but thrive, in this time like no other.