Background: Parenting of children with Developmental Disabilities is considered to be a challenging task. This group of parents are at risk for lower levels of being satisfied with caregiving to their child compared to parents of typically developing children. Methods: Participants were recruited from different services in four provinces across Iran to shape a larger research sample. The Parental Satisfaction with Caring for a child with Developmental Disability Index (PSCDDI) was utilized. Results: Parents of children with DDs particularly parents of children with ASD demonstrated decreased parental satisfaction with caregiving compared with parents of typically developing children. Child behaviour problems, gender and age emerged as a significant predictor of the level of parental satisfaction with caregiving. Conclusions: These findings suggest that understanding parental satisfaction with caring is an important factor in understanding the challenges associated with caring for a child with DD.