Previous research has indicated that the use of case studies is effective for promoting critical thinking, enhancing interest in curricular content, and improving student understanding of core concepts. To prepare students for the challenges of a medical education, the biology faculty at a small, liberal arts college attempts to expose undergraduates to as much clinically relevant content as possible. Clinical cases are used extensively in several courses available to pre-medical biology majors. Here, the integration of clinical cases into three different courses: a 100-level physiology course, a 200-level histology course, and a 300-level biochemistry course is described. The case study method has proven to be extremely flexible. It can be utilized as a laboratory activity, a homework assignment, or an in-class discussion activity.