Objective: To investigate associations between risk in family environments and health-relevant outcomes in college and the role of loneliness. Participants: College students at a state university (N = 360). Methods: We utilized linear regression to examine relationships between risk in family environments and loneliness, perceived stress, affect, and self-rated health. We tested for indirect effects of risk in family environments on outcomes through loneliness Results: Analyses showed that risk in family environments associated with loneliness ([beta] = 0.12 t[358] = 2.22, p = 0.03, R[superscript 2] change = 0.02), perceived social stress ([beta] = 0.20, t[357] = 3.88, p < 0.001, R[superscript 2] change = 0.04), negative and positive affect ([beta] = 2.44, t[357] = 3.95, p < 0.001, R[superscript 2] change = 0.04), and ([beta] = -0.18 t[357]= -3.44, p = 0.001, R[superscript 2] change = 0.03 respectively), and self-rated health ([beta] = 0.19, t[359] = 4.57, p < 0.001, R[superscript 2] change = 0.10). Significant indirect effects were observed for risk in early family on all outcomes through loneliness. Conclusion: These findings provide initial evidence that risk in childhood family environments may negatively affect health by increasing loneliness in college students.