The investigation has demonstrated that the science teaching strategy employed moderates the interest of students in learning the subject, along with academic achievement. In this article we used a mixed method design in a sample of secondary education students (n = 57) to examine the effect of the participative teaching approach in attitudes towards science and student academic performance in the Biology and Geology subject. We also analysed the influence of student learning styles in their academic performance. The statistical results show that the participative methodology has a positive effect on attitude towards student attitudes towards science and academic performance; this finding has been triangulated with class observations and the vision of the teacher participating in the experience. Furthermore, we identified different significances between boys and girls in pre-test academic performance, which disappeared post-test. Despite this, in both measurements the boys showed greater interest in and enjoyment of science learning than the girls. Finally, we are able to conclude that academic performance is positively related to attitude towards science and with reflexive and theoretical learning styles.