This quasi-experimental study was conducted to investigate the effectiveness of PBL (problem-based learning) in a Flipped-Blended learning environment for improving the performance in a Computer Application Course of Bachelor of Economics for first year students at the Muhammadiyah School of Economics Jakarta, Indonesia. The respondents of this research were two groups of students who were enrolled in a Computer Application Course. There were 48 student respondents composed of 24 in the experimental group and 24 in the control group. Findings showed that there were significant differences in the Computer Application Course's performance in the posttest of experimental and control groups, indicating an improvement due to the treatment of the instructional model. In addition, students were challenged and motivated by difficult tasks. This strategy also guides and frees up the time in the classroom.