This study identified the subgroups (latent classes) of Korean college students according to the influence of perfectionism on career stress and indecision, and explored the effects of sub-factors of perfectionism on career stress and indecision for each subgroup. Also, the study examined how individual self-esteem and stress coping styles affect the subgroup classification. Data from 476 South Korean college students were analyzed via mixture regression and logistic regression. Four latent classes were identified. In class 1, career indecision increased as self-oriented perfectionism increased, and career stress increased as socially prescribed perfectionism increased. In class 2, career stress increased as self-oriented perfectionism increased, whereas both career stress and career indecision decreased as others-oriented perfectionism increased. In class 3, both career stress and career indecision increased as others-oriented perfectionism increased. In class 4, career stress and career indecision decreased as others-oriented perfectionism increased, while career stress increased as socially prescribed perfectionism increased. In differentiating the classes, self-esteem and coping styles were analyzed as predictor variables. The results indicated that self-esteem helped to distinguish class 1 from class 2, and class 1 from class 3. Avoidance-oriented coping style could distinguish class 1 from class 3. Career counselors would benefit by noting that the influence of each sub-trait of perfectionism on career-related issues may vary by latent class, and that self-esteem and coping styles may moderate the effects of perfectionism on career-related issues.