e-Learning has been widely used in educational settings especially in developing countries like Indonesia. The purpose of this study was to investigate e-learning readiness among Indonesian university students and to compare students' perceptions of their workload (including mental demand, physical demand, temporal demand, performance, effort, frustration, and sleepiness) in e-learning and classical learning settings. A survey was conducted with students in an Indonesian university. The results show that students have a high level of e-learning readiness. Mental workload is significantly higher in e-learning than in face-to-face learning. No significant difference in sleepiness was found between e-learning and face-to-face learning. The correlation between e-learning readiness and the mental workload was not significant. Implications of the results are discussed.