In this practitioner article, we describe the innovative way the 5E Instructional Model was used in an online, hybrid special education undergraduate course to prepare pre-service teachers to teach academic content to their students with disabilities. We provide a rationale for the use of the model in the course, describe how we implemented the model in the course, pre-service teachers' perceptions about the model as a way to facilitate and model the process of learning for themselves and students, and discuss implications for practice.