The basic objective of this study is to examine whether there is a relationship between spiritual leadership, school culture, and academic success. The data were collected by mixed method from teachers working in seven high schools and five achievement low level high schools in Sanliurfa in 2018. The data obtained from the teachers were analyzed using quantitative and qualitative methods. The conducted analyses revealed two important results. First, it can be claimed that as spiritual leadership perception of teachers increase, so does their school culture perception. The second result is the impact of both spiritual leadership and school culture on academic success. Therefore, the impact of spiritual leadership and school culture on two variables (high success, low success) has been examined separately. As the spiritual leadership and school culture perception of teachers increase, so does academic success.