This study's goal is to examine the relationship between interpersonal problem-solving approaches and personality traits, resilience, and hope levels in university students. Four hundred and one [234 (58.4%) female, 167 (41.6%) male] university students participated in the study. The data were collected using the Interpersonal Problem Solving Inventory, Big Five Inventory, Brief Resilience Scale, and Dispositional Hope Scale. In the study, the relationship between the variables was examined by correlation analysis. Hierarchical regression analysis was conducted to determine the predictability of personality traits, resilience, and hope on interpersonal problem-solving approaches. As a result of the study, a significant positive relationship was identified between approaching problems in a negative way, the lack of self-confidence, and unwillingness to take responsibility and neuroticism, while a significant negative relationship was found between extraversion, agreeableness, responsibility, openness to experiences, resilience, and hope. On the other hand, a significant negative relationship was observed between constructive problem solving and the insistent-persevering approach and neuroticism, while a significant positive relationship was found between extraversion, agreeableness, responsibility, openness to experiences, resilience, and hope. Furthermore, it was determined that neuroticism and resilience significantly explain approaching problems in a negative way; agreeableness, responsibility, openness to experiences, and hope significantly explain constructive problem solving; agreeableness, responsibility, and hope significantly explain the lack of self-confidence; the personality traits of neuroticism and agreeableness significantly explain unwillingness to take responsibility; and agreeableness, openness to experiences, and hope significantly explain the insistent-persevering approach.