Domestic violence is a purposeful use of force or strength on a person within and outside the house which affects the person adversely or the society at large. Therefore, this study examined the influence of domestic violence among Senior Secondary School Girls in Itesiwaju Local Government Area of Oyo State. Ex-post facto research design was adopted. The population comprised all Senior Secondary School Students of Itesiwaju Local Government Oyo State while the target population was 1,280 of which 32 respondents were chosen from the 40 Senior Secondary Schools used for the study. Simple random sampling technique was used to select the schools while purposive sampling technique was used to select the respondents Stratified random sampling technique was used to select the respondents. Questionnaire on the Influence of Domestic Violence among Senior Secondary School Girls (IDVASSGQ) was used to gather information from the respondents. The instrument was subjected to validation and test re-test reliability of 0.74 was realized. Chi square was used to test the hypothesis at 0.05 level of significance. The findings revealed that the level of domestic violence on girl-child among secondary school students in Itesiwaju Local Government Area, Oyo State was high. Findings further revealed that there was a significant influence of domestic violence on girl-child academic performance. Based on the findings, it was recommended that there should be awareness on dangers of violence on girl-child generally. This will educate, sensitise and eradicate all especially the girl-child on the dangers of violence. This will assist students to cope with the social vices associated with the violence especially the girl-child. The society at large should take responsibility of reporting the suspected abuser to the child protection agency or police; this would reduce the rate of violence. Strict laws should be formulated to protect female children generally from domestic violence.