This study aimed to determine the attitudes and metaphorical perceptions of science teacher candidates towards biology lesson. In the study, a mixed method and triangulation pattern was used. A survey form developed by the researchers to determine the metaphorical perceptions of the teacher candidates about biology lesson and their demographic information and a "Biology Course Attitude Scale (BDTÖ)" were used to determine their attitudes towards the biology lesson. SPSS package program was used for analysis of quantitative data and content analysis technique was used for analysis of qualitative data. Metaphores developed by science teacher candidates are alphabetically ordered; coded, categorized, percent and frequency values are calculated. Participant teacher candidates' attitudes towards the biology lesson in general were found to be positive at the "I agree" level. As a result of the research, it was determined that the teacher candidates' attitude scores related to the biology lesson did not show any significant difference according to gender and grade levels. It was determined that science teachers candidates participating in the research had 117 valid metaphors and 57 different metaphors for the biology lesson, and the metaphors of "life" (f = 37) and "water" (f = 6) were the most frequently produced metaphors.