Today's new digital technologies and the spread of the internet have created numerous new opportunities and challenges for the education of the future. The rapid development of mobile and ubiquitous computing technology offered more chances to design and develop innovative learning approach with mobile devices in preparing schools and students for a future. In this paper we present case examples and the research results and reflections based on our recent developments and experiences in Thailand regarding how novel pedagogical applications, mobile technologies and software tools can be combined to enhanced students' learning at all level of education. To the end, we propose a possible direction for the transformation of traditional teaching in science to a novel of mobile and ubiquitous learning in an on-going large-scale educational project in Thailand. This is a challenge of our educational improvement to introduce the novel mobile-assisted learning approach, with the support of mobile devices, into classroom settings, innovative instructional practices and sustainability as the way of future schools in context of Thailand.