Purpose: The study sought to determine whether the onset of canonical vocalizations in children with cochlear implants (CIs) is related to speech perception skills and spoken vocabulary size at 24 months postactivation. Method: The vocal development in 13 young CI recipients (implanted by their third birthdays; mean age at activation = 20.62 months, SD = 8.92 months) was examined at every 3-month interval during the first 2 years of CI use. All children were enrolled in auditory-oral intervention programs. Families of these children used spoken English only. To determine the onset of canonical syllables, the first 50 utterances from 20-min adult-child interactions were analyzed during each session. The onset timing was determined when at least 20% of utterances included canonical syllables. As children's outcomes, we examined their Lexical Neighborhood Test scores and vocabulary size at 24 months postactivation. Results: Pearson correlation analysis showed that the onset timing of canonical syllables is significantly correlated with phonemic recognition skills and spoken vocabulary size at 24 months postactivation. Regression analyses also indicated that the onset timing of canonical syllables predicted phonemic recognition skills and spoken vocabulary size at 24 months postactivation. Conclusion: Monitoring vocal advancement during the earliest periods following cochlear implantation could be valuable as an early indicator of auditory-driven language development in young children with CIs. It remains to be studied which factors improve vocal development for young CI recipients.