The use of online intervention in providing career counseling and guidance is one of the practical methods to help people improve their understanding of their conditions and existing career conditions. This method helps people to take fundamental steps in the decision-making process. Accordingly, the objective of the present study was to investigate the effect of online counseling and face-to-face counseling with a guidance paradigm on career decision-making self-efficacy of students of the University of Isfahan. For this purpose, three groups of students including the face-to-face group, the online group, and the control group were created. Different analyses pre and post tests for these groups showed that students in the online group were similar to students in the face-to-face group in terms of career decision-making self-efficacy and both interventions promoted career decision-making self-efficacy of students relative to the control group.