Exercise has many positive effects on the human organism. In this study, the effects of resistance exercise program, which is applied regularly for eight weeks, were investigated on body composition and some biochemical values. Twenty-four male volunteers participated in the study group. The participants were randomly divided into two equal groups: control and resistance exercise groups. While the participants in the control group attended only practice lessons in the faculty, the exercise group participated in the resistance exercise program 2 days a week for eight weeks in addition to the practice lessons. Body compositions of the participants were measured before and after the program and blood samples were taken. Thus, body weight, body fat percentage, mass body fat, Body mass index (BMI), AST, ALT, GGT, cholesterol, triglyceride, HDL, LDL and VLDL cholesterol levels of the participants were determined. The data obtained were analyzed using SPSS software. As a result of statistical analysis; there was difference only GGT value of the control group (p<0.05). In the exercise group, body weight, body fat percentage, mass body fat, BMI, AST, ALT, GGT values were found to be significant differences (p<0.05). In conclusion, it was determined that resistance exercise program applied for eight weeks had significant effects on body composition and liver enzymes. However, although there are some minor changes in blood lipids, these changes are not statistically significant. It can be said that resistance exercises can be beneficial on liver enzymes and body composition but eight weeks resistance training may not be enough to change the blood lipid profile.