First-Year Seminars (FYS) offer a unique mode of introducing college students to new topics, research practices, and approaches to learning that they may not have been exposed to in high school. In this article, we outline the successes and challenges of team teaching a combined cultural anthropology and biochemistry course on the topic of blood, an aspect of our everyday lives that is both vital and hidden. Using our own experiences in and out of the classroom along with direct student feedback, we discuss the importance and relevance of using interdisciplinary, team-taught FYS to engage, excite, and educate students about the inherent value of thinking and working across disciplinary boundaries.