Approximately seven million students are being raised by LGBTQ+ parents. Marriage equality may prompt more LGBTQ+ families to "come out" to their children's schools. This has implications for school systems, which are inadequately prepared to support these families. Until now, the focus on LGBTQ+ families has been on how they navigate the school system and advocate for themselves. We think that rather than trying to "fit" families into the existing system, an approach that alters the system to support all families is warranted. We review the literature on LGBTQ+ family issues. Next, we define targets for change in the schools: multicultural competency, heteronormativity, and anti-LGBTQ+ prejudice. Then, we review empirically supported prejudice-reduction interventions that can be employed systems-wide. Finally, we describe an approach to systems change that fits well with the overarching goal to create safe, supportive, and inclusive environments for LGBTQ+ families.