In Malaysia, the new teaching model of a flipped classroom is emerging in higher education with the aim of promoting student-centred learning. Hence the main purpose of this study is to identify the students' acceptance level, their perceptions, and the impact of their initial exposures to the flipped classroom model. With this in mind, a survey on undergraduate students' perceptions of the flipped classroom was evaluated at the School of Pharmaceutical Sciences, Universiti Sains Malaysia. Surprisingly, there was a low degree of acceptance and unfavourable impressions of flipped classrooms among students. The reasons were identified to be the inappropriate use of the flipped methodology and the increase of student workload. In conclusion, the implementation of the flipped classroom method was not straightforward in Malaysia with a tradition of more didactic teaching methods.