The Information Systems discipline has long suffered an identity crisis. It has also been prone to program sustainability issues as a technology focus has waxed and waned over the last 50 years. This paper suggests a new approach to teaching Information Systems, utilizing the notion of "fundamental and powerful concepts." Using digital disruption as a fundamental and powerful concept, the authors argue for the core IS course and the courses that make up the major to be developed and centered around the transformation of business models, products, and services caused by emerging digital technologies. The paper includes an outline for the core IS course and the other courses in the major and concludes with a suggestion that the fundamental and powerful concept of digital disruption be used as an approach to teaching Information Systems.