The study employed survey design in investigating the knowledge of the Sexually Transmitted Diseases STDs in Kaduna metopolitant, Kaduna State, Nigeria. A Sample of 237 (caregivers and adolescents) was used for this study. Four research questions and four null hypotheses were formulated. Statistical means was used to answer the research questions and t-test was used in testing the null hypotheses. The results show that: caregivers and adolescents know very little about the forms of STDs, the students have moderate knowledge of the signs and symptom of various STDs, male and female caregivers had agreed with mode of transmission, and the control measures toward STDs. Based on the above findings recommendations were made among which are: School Psychologists, counsellors should continuously sensitize the caregivers and adolescents, and organize group guidance programme in school on personal health and risky behaviour, and there should be synergy between health twisters, school administrators and parents in creativity awareness among caregivers and adolescents on the risk factors, symptom and control of STDs, and voluntary HIV test before marriage, poverty alleviation programme to re address the epidemics among others are made.