This article highlights roles and responsibilities in design-based research (DBR) by analysing the micro-communication processes between two science teachers and one researcher. Despite DBR being a practice-oriented methodology, we know little about micro-communication processes with regard to how roles and responsibilities are fulfilled and perceived. We draw upon certain concepts from frame analysis when exploring three areas of concern: (1) the participants' framing of their own and each other roles and responsibilities, (2) the flexible researcher role in micro-communication processes, and (3) the teachers' different framing of education and research. Our analyses reveals that the researcher's role is framed as an observer while the teachers are the ones who implement the artefact being tested. Additionally, the flexible researcher appears more equipped to handle micro-communication processes and the teachers' different framing can be useful for development of the study. Finally, we present some final reflections based on our findings.